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revised 08-Apr-2016

Pediatric Multiple Sclerosis


Multiple Sclerosis and other demyelinating diseases of the central nervous system in the pediatric population have received an increasing level of attention by clinicians and researchers in recent years. Qualities of the pediatric population such as close proximity to biological disease onset and maturing innate and adaptive immune pathways provide unique opportunities to study disease pathogenesis. The opportunity to conduct high-impact research in this area is best pursued through multi-institutional collaborations given the low incidence of these diseases in the pediatric population.  


The Network of Pediatric Multiple Sclerosis Centers (NPMSC) is a United States network comprised of adult and child neurologists, scientists and other research professionals whose unifying mission is to uncover the key pathogenic mechanisms underlying multiple sclerosis through the study of pediatric multiple sclerosis. Through ongoing studies, the NPMSC is measuring clinical, environmental, and cognitive manifestations of early onset MS and growing the largest collection of well-characterized pediatric MS cases in the world. 


Network Updates



Recent Research Presentations



These posters and presentations are available on the ACTRIMS 2016 online library:


  • Gut Microbiota Composition and Relapse Risk in Pediatric MS
  • Associations Between Gut Microbiota and Immune Markers in Pediatric Multiple Sclerosis and Controls
  • First Genome-Wide Analysis in Pediatric Multiple Sclerosis (MS) Confirms a Role for Adult MS Risk Variants and Reveals New Candidates
  • Increased Body Mass Index is Causually Associated with Pediatric MS Onset: A Mendelian Randomization Study
  • The Causal Effect of Serum Vitamin D Levels on Pediatric Multiple Sclerosis: A Mendelian Randomization Study



These posters and presentations are available on the ECTRIMS 2015 online library:


  • Effect of Obesity and Puberty on Risk and Age at Onset of Pediatric Multiple Sclerosis
  • Association of Dietary Salt Intake and Relapse Rate in Pediatric Multiple Sclerosis
  • Acquisition of Early Development Milestones and Need for Special Education Services in Pediatric-Onset Multiple Sclerosis
  • The Geographic Distribution of Pediatic MS in the US
  • Pregnancy Exposures and Risk for Pediatric Onset MS











Resources for Researchers


The National MS Society and other organizations support a variety or research tools and information resources that may be useful in your research and/or clinical programs. Click the link below for information on tissue/DNA banks, datasets, clinical measures, trial recruitment and much more.